Statistical analysis shows that in the present scenario, one in six couples have an infertility problem and the male member is responsible for 50 percent of the cases1. Almost 35 percent cases have varicocele and in 25 percent cases, idiopathic infertility is the reason behind the male infertility. However, urogenital infections,
endocrine disorders, immunologic factors, genetic abnormalities, and congenital disorders are other causes of male infertility.
Semen is ejaculated from the male reproductive organ, which contains sperm. A mature sperm cell or spermatozoa is a key element of male fertility. But the functionality of spermatozoa is compromised by elevation of reactive oxygen species level2. It is well known that oxygen is essential for life, but due to its strong oxidizing property, it causes free radicals formation within the cellular structures and consequences of
this lead to series of structural and functional changes in the organs. Various external factors, including unhealthy lifestyle and exposure to environmental toxic chemicals, often influence free radicals formation within the cellular structures. The most common free radicals like superoxide anions, hydroxyl radicals, and hypochlorite radicals are collectively known as reactive oxygen species (ROS). Researchfindings supported that increased burden of ROS plays an important role in male infertility.