Methylcobalamin in Diabetic Neuropathy

Methylcobalamin in Diabetic Neuropathy

Insulin is a hormone secreted¬†from pancreatic ő≤- cells to utilize¬†glucose (the smaller unit of edible¬†carbohydrate) and provides energy¬†to every body cells for perform¬†cellular functioning. Diabetes is¬†a condition in which blood glucose¬†level is significantly higher¬†(hyperglycemia) than the normal¬†range. Impaired functioning of¬†insulin is¬† primarily responsible¬†for this disease development.¬†Chronic and progressive diabetic¬†condition impairs overall
physiological condition by¬†damaging blood vessels, heart,¬†kidney, nerves and eyes. The¬†involved pathophysiology of¬†diabetes mainly develops either¬†due to impaired pancreatic ő≤- cells¬†functioning leads to insufficient¬†insulin synthesis or body unable to¬†utilize produced insulin properly.¬†According to WHO estimation,¬†globally four hundred twenty two¬†million adults have diabetes in¬†2014. This value is almost four
times greater than the estimated diabetes incidence in 1980.2 Type1 and type 2 and gestational diabetes
are three broad categorization¬†of diabetes. Among these three¬†types, gestational diabetes is not a¬†prolonged condition, as it develops¬†during pregnancy and after child¬†birth, blood glucose level become¬†normalized. However, sometimes¬†gestational diabetes an indication¬†of type 2 diabetes, which may¬†develop in future. Type 1 diabetes¬†is an auto-immune disorder, in¬†which body‚Äôs own immune system¬†destroys pancreatic ő≤- cells and
insulin synthesis is reduced. Type 1 diabetes is a inherited condition and can occur at any age.1 The exact etiology of type 1 diabetes is unknown.3 Type 2 diabetes usually develops in middle aged people and is the most common form. The hyperglycemic condition in type 2 diabetes can develop either due to insufficient insulin synthesis, or body unable to utilize insulin properly. Both insulin insufficiency and insulin resistance along with hyperglycemia are characteristic features of type 2 diabetes.4